Makati is located within the quadrangle of 12′011″ °north and 14′331″ °E right at the center of Metro Manila. The city is bounded on the north by the Pasig River, facing Mandaluyong City, on the northeast by Pasig City, on the southeast by the municipality of Pateros and Taguig City, on the northwest by the City of Manila, and on the southwest by Pasay City. Makati has a total land area of 27.36 square kilometers; it constitutes 4.3 % of Metro Manila's total land area.
At the center of the city is the Central Business District (CBD) where many companies in the Philippines have their offices or headquarters. This is where many of the country's tallest skyscrapers are located. The Makati skyline is one of the most impressive sights in Metro Manila.
 Two of Metro Manila's main arteries pass through Makati. The Epifanio De los Santos Avenue (EDSA) pass along the southeast part of Makati and connects the city with Mandaluyong City and Pasay City. The South Luzon Expressway (SLEX) runs through the western part of Makati and connects the city with Manila to the north and with southern Metro Manila. The Skyway, an elevated highway built on top of SLEX, provides residents coming from southern Metro Manila a fast way to reach Makati. SLEX and EDSA intersect at the Magallanes Interchange, which is the most complex system of elevated roadways in Metro Manila.
Other major roads in Makati include Buendia Avenue, also called Sen. Gil Puyat Avenue, which connects EDSA and SLEX in the north; Ayala Avenue, an important street that runs through the Central Business District; and Makati Avenue, which connects Ayala Avenue with Buendia Avenue, also extending north to cross the Pasig River to Mandaluyong City. At the center of Makati is the Ayala Triangle, a park built on the former Nielsen Air Base.
Makati's sister city is Los Angeles, California. Makati is also twinned with Ramapo, New York.
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